A novel and efficient synthesis of pyrogallol moiety through a copper(I)-mediated C–O bond forming reaction is described. In particular, syntheses of 3,4,5-trihydroxyphenethyl alcohol and its methyl derivative are reported. Particular attention to dimethyl carbonate as an eco-friendly solvent/reactant has been paid, in order to improve the eco-compatibility of the whole synthetic pathway. Furthermore, the genotoxicity, cytotoxicity and the antioxidant activity of 3,4,5-trihydroxyphenethyl alcohol and its methyl derivative have been investigated.
|Autori:||Barontini, M.;Proietti Silvestri, I.;Nardi, V.;Crisante, F.;Pepe, G.;Pari, L.;Gallucci, F.;Bovicelli, P.;Righi, G.|
|Data di pubblicazione:||2013|
|Titolo:||Synthesis and biological evaluation of gallic acid analogs.|
|Rivista:||MEDICINAL CHEMISTRY RESEARCH|
|Appare nelle tipologie:||1.1 Articolo in rivista|