Background: Sleep patterns face important changes during adolescence. This can have implications for the immune system, which is regulated by the sleep–wake cycle; however, most studies relating sleep and immune system have been conducted on adults. Objective: To study the relationships between sleep duration, immune cell counts, and cytokines in Eu- ropean adolescents participating in the HELENA Cross-Sectional Study. Methods: Adolescents(12.5–17.5years;n=933;53.9%girls)weregroupedaccordingtoself-reportedsleep duration into <8, 8–8.9 and ≥9 h/night. Blood samples were collected in the morning after an overnight fast to analyze counts of white blood cells (WBC), neutrophils, lymphocytes, monocytes, eosinophils, ba- sophils, the lymphocyte subsets CD3+, CD4+, CD8+, CD45RA+, CD45RO+, CD3−CD16+56+ and CD19+, and con- centrations of cortisol, CRP, IL-1, IL-2, IL-4, IL-5, IL-6, IL-10, TNF-α and IFN-γ. Pro-/anti-inflammatory and Th1/Th2 cytokine ratios were calculated. Immune parameters were correlated to sleep duration and com- pared between the three groups. Results: Sleep duration was negatively associated with cortisol levels and WBC, neutrophil, monocyte, CD4+ and CD4+CD45RO+ counts; in girls it is also negatively associated with IL-5 and IL-6 levels. The 8–8.9 h/night group presented the highest IL-4 values and the lowest pro-/anti-inflammatory and Th1/Th2 cytokine ratios. Conclusion: A sleep duration of 8–8.9 h/night was associated with a healthier immune profile in our adolescents.
|Autori:||Heredia, F.P.;Garaulet, M.;Gomez-Martinez, S.;Diaz, L.;Wurnerg, J.;Androutsos, O.;Michels, N.;Cuenca-Garcìa, M.;Huybrechts, I.;Gottrand, F.;Ferrari, M.;Santaliestra-Pasías, A.M.;Kafatos, A.;Molnár, D.;Sjöstrom, M.;Widhalm, K.;Moreno, L.A.;Marcos, A.|
|Data di pubblicazione:||2014|
|Titolo:||Self-reported sleep duration, white blood cell counts and cytokine profiles in European adolescents: the HELENA study|
|Appare nelle tipologie:||1.1 Articolo in rivista|