Background and aims: Stress is hypothesized to facilitate the development of obesity, whose the foundations are already set during childhood and adolescence. We investigated the relationship between the stress-system, selected mechanisms of energy homeostasis and insulin resistance (IR) in a sample of European adolescents. Methods and results: Within HELENA-CSS, 723 adolescents (12.5e17.5 years) from 10 European cities provided all the necessary data for this study. Fasting blood samples were collected for cortisol, leptin, insulin and glucose analysis. HOMA-IR was calculated from insulin and glucose concentrations. Adolescents’ body fat (BF) %, age and duration of exclusive breastfeeding were assessed. For boys and girls separately, the relationship of cortisol with leptin, insulin, glucose and HOMA-IR was examined by computing Pearson correlation coefficients and Hierarchical Linear Models (HLMs), with ‘city’ as cluster unit, adjusting for age, BF% and duration of exclusive breastfeeding. In boys, Pearson correlation coefficients illustrated positive correlations of cortisol with insulin (r Z 0.144; p Z 0.013), glucose (r Z 0.315; p < 0.001) and HOMA-IR (r Z 0.180; p Z 0.002), whilst in girls, this positive relationship was observed for leptin (r Z 0.147; p Z 0.002), insulin (r Z 0.095; p Z 0.050) and HOMA-IR (r Z 0.099; p Z 0.041), but not for glucose (r Z 0.054; p Z 0.265). Observed associations were independent of adolescents’ age, BF% and duration of exclusive breastfeeding after computing HLMs.
|Autori:||Huybrechts, I.;De Vriendt, T.;Breidenassel, C.;Rogiers, J.;Vanaelst, B.;Cuenca-García, M.;Moreno, L.A.;González-Gross, M.;Roccaldo, R.;Kafatos A.;Clays, E.;Bueno, G.;Beghin, L.;Sjöstrom, M.;Manios, Y.;Molnár, D.;Pisa, P.T.;De Henauw, S. on behalf of the HELENA Study Group|
|Data di pubblicazione:||2014|
|Titolo:||Mechanisms of stress, energy homeostasis and insulin resistance in European adolescents e the HELENA study*|
|Rivista:||NMCD. NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES|
|Appare nelle tipologie:||1.1 Articolo in rivista|