Abstract Percentiles 10th, 25th, 50th, 75th and 90th are pre- sented for circulating white blood cells (WBC), neutrophils, lymphocytes, monocytes, eosinophils and basophils in healthy European adolescents (12.5–17.5 years, n = 405, 48.9 % boys), considering age, sex, puberty and body mass index (BMI). CD3+ (mature T cells), CD4+ (T helper), CD8+ (T cytotoxic), CD16+56+ (natural killer), CD19+ (B cells), CD3+CD45RA+, CD4+CD45RA+, CD8+CD45RA+ (naïve), CD3+CD45RO+, CD4+CD45RO+ and CD8+CD45RO+ (memory) lympho- cytes were also analysed by immunophenotyping. Girls presented higher WBC, neutrophil, CD3+CD45RO+ and CD4+CD45RO+ cell counts and CD3+/CD19+ ratio, and lower CD3+CD45RA+ and CD4+CD45RA+ counts than boys. Age was associated with higher neutrophil counts and CD3+/CD19+, and lower CD19+ counts; in boys, with lower CD3+ CD45RA+ , CD4+ CD45RA+ and CD8+CD45RA+ counts as well; in girls, with higher WBC, CD3+CD45RO+ and CD4+CD45RO+ counts. Pu- bertal maturation in boys was associated with lower WBC and lymphocyte counts; in girls, with higher ba- sophil, CD3+CD45RO+ and CD4+CD45RO+ values. BMI was associated with higher WBC counts; in boys, also with higher lymphocyte counts; in girls, with higher neutrophil, CD4+, CD3+CD45RO+ and CD4+CD45RO+ counts. Conclusion: Our study provides normative values for cir- culating immune cells in adolescents, highlighting the impor- tance of considering sex, age, pubertal maturation and BMI when establishing reference ranges for WBC in paediatric populations.
|Autori:||Perez-Heredia, F.;Gomez-Martinez, S.;Esperanza-Diaz, L.;Veses, A.M.;Nova, E.;Warnberg, J.;Huybrechts, I.;Wyncke, K.;Androutsos,O.;Ferrari, M. ;et al|
|Data di pubblicazione:||2015|
|Titolo:||Influence of sex, age, pubertal maturation and body mass index on circulating white blood cell counts in healthy European adolescents—the HELENA study|
|Appare nelle tipologie:||1.1 Articolo in rivista|